Effect of lidocaine on ischaemic preconditioning in isolated rat heart
نویسندگان
چکیده
منابع مشابه
ischaemic preconditioning in isolated rat heart
Objective: To assess whether the protective effect of ischaemic preconditioning (IPC) on endothelial function in coronary arteries of the rat involves prostaglandins. Methods: Isolated rat hearts perfused under constant flow conditions were exposed to 30 min of partial ischaemia (flow-rate 1 ml /min) followed by 20 min of reperfusion, after which coronaries were precontracted with U-46619 0.1 m...
متن کاملImproved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart.
OBJECTIVE A brief period of ischaemia (5 min) and reperfusion (5 min), prior to a longer period of ischaemia and reperfusion, has been shown to reduce the extent of injury (necrosis, arrhythmias, or postischaemic contractile malfunction) caused by a subsequent longer period of ischaemia and reperfusion. Adenosine has been identified as a factor in the protection afforded against regional tissue...
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Introduction: Beat-to-beat variation in heart rate shows a complex dynamics, and this complexity is changed during systemic inflammatory response syndrome (e.g. sepsis). It is not known whether or not cardiac pacemaker dynamical rhythm is affected by sepsis. The aim of this study was to investigate heart rate dynamics of isolated heart as well as expression of pacemaker channels (HCN) in a r...
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Objective: Oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. This study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin E by the eNOS and iNOS express gene in ischemia/reperfusion in rats. Material & Methods: Male rats were divided into seven groups, namely: sham, control group and ex...
متن کاملCardioprotective Effect of Garlic Juice on the Isolated Rat Heart in Ischemia- Reperfusion
Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in is...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2004
ISSN: 0007-0912
DOI: 10.1093/bja/aeh262